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Evaluating MF-CTCL requires a combination of clinical findings and pathologic criteria1,2

Evaluating MF-CTCL Evaluating MF-CTCL
  • Clinical examination, skin biopsy, and bloodwork are necessary for diagnosis2
  • Other screening tests such as a CT or PET scan may be indicated, depending on the patient’s history3

NCCN Clinical Practice Guidelines In Oncology (NCCN Guidelines®) recommended laboratory tests for MF-CTCL2:

  • Complete blood count (CBC) with differential and determination of absolute lymphocyte count
  • Sézary flow cytometric studies to assess and quantitate an expanded T-cell population with aberrant population (optional for T1)
    • Recommended for any patient with T2-4 skin classification, any suspected extracutaneous disease including adenopathy
  • Review of slides by pathologist with expertise in the diagnosis of CTCLs
  • Molecular analysis to detect clonal TCR gene rearrangement in peripheral blood lymphocytes if blood involvement suspected
  • Comprehensive metabolic panel
  • Lactate dehydrogenase (LDH)
  • Pregnancy testing women of child-bearing age

Unresponsive or recurrent lesions may be a reason to biopsy for MF-CTCL2

References:

  1. Song SX, Willemze R, Swerdlow SH, Kinney MC, Said JW. Mycosis fungoides: report of the 2011 Society for Hematopathology/European Association for Haematopathology workshop. Am J Clin Pathol. 2013;139(4):466-490.
  2. Referenced with permission from the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) for Primary Cutaneous Lymphomas V.2.2021. © 2021 National Comprehensive Cancer Network, Inc. All rights reserved. Accessed July 10, 2021. To view the most recent and complete version of the guideline, go online to NCCN.org. NCCN makes no warranties of any kind whatsoever regarding their content, use or application and disclaims any responsibility for their application or use in any way.
  3. Cutaneous Lymphoma Foundation. Mycosis fungoides. Cutaneous Lymphoma Foundation website. https://www.clfoundation.org/mycosis-fungoides. Accessed July 10, 2021.